In a study done by Dr. S.
T. Sonis and Dr. Lieberman says that 39% of 93 randomly selected patients with cancer not of the head and neck had oral complications associated with their treatment. The age of the patient, type of malignancy and type of treatment were importuned factors affecting the prevalence of these complications, they also found that xerostomia, oral ulcers and infections were the most common complications which indicates the need for an awareness and involvement of dental practitioners in their management. Another study about chemotherapy and radiotherapy induces oral mucositis showed that it affects 20%to 40% of the patients receiving chemotherapy for solid tumors depend on the dose and cytotoxicity of the drug. Its seen in 80% of patient receiving very high doses of chemotherapy before hematopoietic stem cell transplantation. Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy, the study design was longitudinal, 1 month after the initiation of chemotherapy 45 patients were evaluated and monitored for. The results show an increase in the number of mucositis cases and a decrease in xerostomia cases after the initiation of treatment, other oral lesions were found but in low numbers.
oral Complications of Chemotherapy and Head-Neck Radiation showed that: Ulcerative oral mucositis occurred in 40% of patients receiving chemotherapy,50% of these patients have severe lesions that require medical intervention. Intensive chemotherapy can cause ulcerative mucositis that appears approximately 2 weeks after the start of high-dose chemotherapy. mucositis caused by agents such as 5-fluorouracil (5-FU) by reducing vascularity to the replicating epithelial cells .Other oral complications typically include infections of the mucosa, dentition and periodontium. In addition, selected chemotherapeutic agents can be one agent or combination of more than one have been implicated in causing salivary disorders and xerostomia ,but it has not been possible to draw consistent conclusions about the effects of cancer chemotherapy on salivary gland function.
This study was done to determine xerostomia in cancer therapy: in examination done to patients receiving chemotherapy 50% of them had ductal dilatation, cyst formationwithin the glandular tissue, acinar degeneration and infiltration of inflammatory cells in minor salivary gland tissue but its impact and effect on oral health is still not clear therefore more studies are needed to determine the exact oral effects on salivary glands function . Another study was done to check the severity and prevalence of salivary gland hypofunction and xerostomia its impact on patient’s life quality: some data records have been collected form MEDLINE/PubMed and EMBASE results found 184 articles covering xerostomia and salivary hypofunction on patients receiving chemotherapy, radiotherapy and other types of malignancy treatment. Radiotherapy was the most leading cause of salivary hypofunction but other medications like chemotherapy and immunotherapy